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Pharmacology Of Hypertension And Hyperlipidemia Essay

714 words - 3 pages

Atenolol is a Beta adrenoceptor Antagonist which is more efficient in Blocking Beta 1 receptors. It is one of the most used drugs for treating hypertension since it is a cardioselective drug. It lowers the blood pressure and the heart rate and may be safe for asthmatics. The main indication is for angina pectoris, hypertension and arrhythmias. Its main action is to prevent sympathetic vasoconstriction and to reduce prostatic smooth muscle tone. One of the main problem with taking atenolol is that a daily dose is not sufficient and the behavior of the patient towards taking the drug continuously is dependent on this.
Doxazosin is an Alpha 1 Blocker. It selectively blocks alpha 1 receptors in ...view middle of the document...

Sertraline is a selective serotonin reuptake inhibitor (SSRI). It is an antidepressant drug which selectively blocks the Serotonin transporter (SERT). It exists as an isomer and is formulated in the racemic form. It is indicated for patients suffering from major depression, anxiety disorders, obsessive compulsive disorders and post-traumatic stress disorders. One of the adverse effects of this drug is weight gain. It is also associated with a discontinuation syndrome that manifests as dizziness and paresthesia that happens when the drug is discontinued for 1 to 2 days. This may be the reason why the patient has recently gained 9 pounds. Patient behavior is also a factor to be considered because the patient’s behavior in taking the drugs is crucial since Sertraline is known to cause a discontinuation syndrome.
Simvastatin is a structural analog of HMG-CoA. This is one of the most effective drugs in reducing LDL. It also reduces oxidative stress and vascular inflammation and increases the stability of atherosclerotic lesions. It is affected by the first pass effect through the liver ad is mainly excreted in bile. It causes partial inhibition in the enzyme HMG-CoA reductase which is needed for sterol synthesis which...

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