This website uses cookies to ensure you have the best experience. Learn more

Parkinson Essay

1569 words - 7 pages

Parkinson's Disease and Stem Cell Treatment




Parkinson's disease is a neurogenerative disease characterized by a progressive loss of the dopaminergic neurones in the substantia nigra, pars compacta in the midbrain ( Borta & Hoglinger, 2006). Stem cells derived from embryos or fetal tissues have been introduced in the clinic as an alternative treatment for parkinson’s disease. Because of their self-renewal capacity and pluripotentiality, human embryonic stem cells are thought to hold enormus promise as potential replacement tissue in neurodegenerative disease such as Parkinson’s. Pluripotential embryonic stem ...view middle of the document...

A major advance in the understanding of Parkinson's disease (PD) came when dopamine deficiency was discovered in the corpus striatum and substantia nigra (SN) of brains taken from patients. Later studies demonstrated the connection between the SN and the striatum, thus suggesting that dopaminergic cell loss in the SN directly leads to dopaminergic deficiency in the striatum. The determination that PD is a disease of dopamine loss led to the development of rational therapies aimed at correcting this deficiency. Experimental therapeutics of PD includes novel delivery systems, anti-apoptic strategies and implantation of genetically engineered cells, and stem cells (Jankovic, 2006).
Stem cells have been widely assumed to be capable of replacing lost or damaged cells in a number of diseases, including Parkinson's disease, in which neurons of the substantia nigra die and fail to provide the neurotransmiter, dopamine, to the striatum (Redmond et al, 2007). Neural stem cells possess high potencies of self-renewal and neuronal differentation. As the neural stem cells most primordial cells, the human neural stem cells have attributes that appear to promote anatomical and functional preservation and/or restoration in neurodegenerative diseases. Pluripotential embryonic stem cells, neural tissue derived stem and phenotype-specified progenitor cells have been investigated for their ability to generate neurons and glia, and the molecular mechanism by which they do so (Redmond et al, 2007). Some works focus on the potential utility of neural stem cells and progenitor cells as substrates for structural repair of the brain.
Embryonic stem cells as source of

Dopaminergic neurons

Stem cells are undeveloped cells capable of proliferation, self-renewal, conversion to differentiated cells, and regenerating tissues. There are two main types of stem cells, embryonic and nonembryonic. Embryonic stem cells are derived from the inner cell mass of a blastocyst, which forms several days after an egg is fertilized. If the blastocyst implants into the uterus, the inner cell mass will develop into a fetus, with the surrounding trophoblast developing into the placenta (Iacoviti et al, 2007). The cells in this line are pluripotent and will differentiate under appropriate culture conditions into the three lineages of: ectoderm, endoderm and mesoderm, from which all mature cells, will develop. Ectodermal cells are the source of neuronal cells such as those containing (releasing) dopamine, and are essential to treat Parkinson’s disease.
Umbilical cord matrix stems (UCMS) cells
Umbilical cord matrix stem (UCMS) cells have several properties that make them of interest as a source of cells for therapeutic use. For example, they can be isolated in large numbers, grow robustly and can be frozen/thawed, can be clonally expanded, and can easily be engineered to express exogenous proteins UCMS cells have genetic and surface markers of mesenchymal stem cells and appear to...

Other Papers Like Parkinson

Mediation in Family Essay

1519 words - 7 pages family mediators and counselors undoubtedly similar with some common areas of knowledge and skills, it is important to state that the role of mediator differs in many important aspects from the role of counselor. According to Parkinson and Robinson (2011), differences between counselors and family mediators are as below. For counselors, individual may be seen alone and counsel one partner sometimes. It is obviously that counseling issue almost all

The Germanic and Celtic Tradition by George MacDonald

1000 words - 4 pages underground-dwelling creatures of myth and George MacDonald's goblins is their shared dislike for music. The Knockers, mine spirits believed to have frequented the mines of the 18th and 19th century Cornwall, were offended by whistling, among other things, and would play dangerous tricks on those who had offended them (Parkinson and Topham). MacDonald's goblins "can't bear singing" (35). They flee at the sound of it, allowing the miners to use it as a

Ecosystems Effecting Healthcare

1644 words - 7 pages -on-admission’ conditions is limited to experience and time consuming. Today, the focus at John Hopkins indeed is on quality health care and is currently participating in a national quality initiative program, specifically for the Johns Hopkins Parkinson’s Disease and Movement Disorders Center. Parkinson disease (PD) affects millions of people worldwide. With no cure and no effective ways to prevent it, PD is a huge public health challenge. The

Emirates Airline

1593 words - 7 pages flexibility, the company runs a unique model of business making it a global leader in long haul flights across the globe. Effective pricing strategy makes sure that passengers pay cheaper air tickets, but enjoy the flights (Meek, Palmer and Parkinson 52). This is a big boost to its competitive advantage. The cost-effective advantage gives passengers the reason to prefer the airline over other competitors. It is necessary to highlight that the long haul

Gene Therapy

582 words - 3 pages patient suffered from age-related macular degeneration or retinitis pigmentosa as it can be applied safely before the beginning of vision loss. Thus, there is still hope for them to be safely cured. Gene therapy can give positive result in curing or giving patient suffering from hardly cured disease. Another clinical trial has also been done to patient suffering from Parkinson Disease and surprisingly it gives promising result too. They underwent

The Problem Of Resource Depletion

2271 words - 10 pages protect resources that are not priced or incorrectly priced. Correcting the prices anomaly would have huge consequences for businesses. For instance, the calculations have shown that more than a quarter of profits of the world's biggest companies would be wiped out if water was priced to reflect its value. (Parkinson, 2014) Also, the following method can include the creation of the organizations targeted towards the regulation of the consumption of

Health Information Exchange

1212 words - 5 pages Devry 11 Health Information Exchange A Necessary System? James Parkinson Health Information Exchange A Necessary System? By James Parkinson TABLE of CONTENTS Pg 3……..Introduction Pg4, 5…..Chapter 1, The History of Information Exchange Pg 6, 7…. Chapter 2, Challenges and Benefits of an HIT System Pg 8……..Chapter 3, The Role of Networks, How Multiple Users Need for Data and Data Exchange are met Pg 9

Dance Therapy for Parkinson's Patients

2854 words - 12 pages Introduction “Parkinson’s disease (PD) is a progressive, neurodegenerative disease that belongs to the group of conditions called motor system disorders”. PD cannot yet be cured and patients get worse over time as the normal bodily functions, including breathing, balance, movement, and heart function worsen. The most common type of Parkinson disease is idiopathic Parkinson’s disease (PD), first described by James Parkinson, an English

Trends in Therapeutic Partnering Market Trend and Share

2696 words - 11 pages In Numbers top Nutrition & Vitamins Partnering Deals By Value most Active Nutrition & Vitamin Partnering Companies 13. Solid Tumor solid Tumor Partnering In Numbers top Solid Tumors Partnering Deals By Value most Active Solid Tumor Partnering Companies 14. Parkinson’s Disease parkinson’s Disease Partnering In Numbers top Parkinson’s Disease Partnering Deals By Value most Active Parkinson’s Disease Partnering Companies 15

The Great Debate Over Stem Cells Research

2199 words - 9 pages could lead to major medical advancements. It could be used to treat countless diseases, including Parkinson disease, and possibly Alzheimer's, and therefore improve the lives of millions. Stem cells have already been tested on some human patients and shown results. So, a use for them could come in the very near future. In addition, looking farther into the future stem cell research holds all kinds of possibilities. Imagine if doctors could

Frl 408 Term Paper

2523 words - 11 pages relationship, the agreement between these two entities, is agreed upon a mutual trust. The agent agrees to performance, accounting, loyalty obedience, and lastly notification. When it comes to obedience, agents must abide to the principal’s instructions, as long as it is legal. Obedience and loyalty can be the most difficult thing when one is dealing with an unethical person. For example, (Parkinson, 2006) puts a situation like this, “A producer of

Related Essays

Parkinson Disease Essay

1759 words - 8 pages pamphlets, the first distinct medical account was written in the year 1817 by James Parkinson. During the mid-1800s, Jean-Martin Charcot was predominantly dominant in expanding and refining this early account and in publicizing info globally regarding the Parkinson's illness. He detached Parkinson's ailment from numerous sclerosis and other conditions depicted by tremor, and he acknowledged incidents that later would possibly be categorized amongst the

Explain How Two Foods Can Improve Your Health

619 words - 3 pages various ways. One of the main way of health improvement by green tea is to inhibit the growth of cancer cells. For example, an epidemiological study in Chinese males and females indicated that drinking green tea reduced the risk of esophageal cancer, this is because of it is rich in catechin polyphenols (Parkinson 2000). Another mean by which health can be improved by green tea is beneficial to cholesterol levels. It contributes to the body’s

Parkinson's Disease Essay

897 words - 4 pages disease. This means people with Parkinson disease may not have the mechanisms needed to get rid of the unstable molecules that linger around in the brain and body (David et al., 2009). Sex, race, and age. It is very uncommon for children to develop this disease. However, the mean age of Parkinson’s disease is 62 and it occurs most often to adults between the ages of 40-80 (Allison, Bradley, Min, Susan, & Brad, 2010). In terms of gender, men are

Bureaucracy Max Webber Essay

680 words - 3 pages bureaucratic form, according to Parkinson, has another attribute. 7. Predisposition to grow in staff "above the line." Weber failed to notice this, but C. Northcote Parkinson found it so common that he made it the basis of his humorous "Parkinson's law." Parkinson demonstrated that the management and professional staff tends to grow at predictable rates, almost without regard to what the line organization is doing. The bureaucratic form is so