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Mice And Men Essay

974 words - 4 pages

cytes. In this case, the small size of
siRNAs may have led to greater hepatic
RNA interference gene therapy
........................................................................ transfection efficiency resulting in rela-
tively successful in vivo RNAi.
A story of mice and men ...view middle of the document...

How-
dependent protein kinase response (PKR)
RNA interference (RNAi) has emerged as
ever, the work of Gitlin et al9 sounds a
causes global, non-specific repression of
one of the hottest topics in molecular and
note of caution for the field. They found
translation in response to dsRNAs longer
organismal biology. A flurry of recent
that polio escape mutants, with silent
than 30 nucleotides, thus masking any
papers suggest that RNAi may be useful
point mutations in the middle of the tar-
RNAi-based silencing. However with
as a human therapeutic. Significantly, in
get sequence, emerged after treatment
shorter dsRNAs (short interfering RNAs
a paper in September’s Nature Genetics,
with RNAi.9 Thus, it may be necessary to
or siRNAs) Elbashir et al, in their ground-
David Lewis and his colleagues have
attack viruses with multiple RNAi
breaking study, were able to silence
shown that RNAi is functional in numer-
sequences simultaneously to prevent the
ous tissues of therapeutic interest.1 genes in mammalian cells without trig-
...

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