| | | | |
Blog Male birth control pill moves a step closer16th August 2012Researchers have finally found a compound that may offer the first effective and hormone-free birth control pill for men.The study, published today in the journal Cell, describes how the small molecule makes male mice reversibly infertile, without putting a damper on their sex drive. When the animals stop taking this new form of birth control, their sperm rebound and they are able to produce perfectly healthy offspring once again."This compound produces a rapid and reversible decrease in sperm count and motility with profound effects on fertility," said James Bradner of the Dana-Farber Cancer Institute and lead author of the study.A male birth control pill has been difficult to come by, in large part because of the challenge of getting any drug across the blood:testis barrier, where it can reach the sperm-generating cells. That lack of contraceptive alternatives for men is partially ...view middle of the document...
Mating studies confirm that JQ1 indeed works as an effective contraception. Even better, those effects are completely reversible and without adverse consequences for the animals' testosterone levels or behavior. The small molecule also comes without any apparent side effects on the males' future offspring."There has not been a new reversible contraceptive for men since the development of the condom, centuries ago," notes William Bremner from the University of Washington, Seattle. In an accompanying commentary, he refers to Matzuk and Bradner's contraceptive method as "a breakthrough new approach.""We envision that our discoveries can be completely translated to men, providing a novel and efficacious strategy for a male contraceptive," the researchers wrote, noting the high degree of conservation between human and mouse BRDT proteins. | | | | |
In 1960, an invention revolutionized female sexuality and paved the way for the women’s liberation movement. It was the birth-control pill, or simply “the pill” as it became popularly known. For four decades, the pill has put women primarily in the contraceptive driver’s seat. But an increasing number of people — both men and women — want men to take a more active role in contraception use. Their wish may be granted in the foreseeable future, as research companies grow closer to revealing the first continuous, reversible male contraceptive pill. Researchers at Edinburgh University’s Centre for Reproductive Biology have finally found a way to suppress daily sperm production while maintaining normal testosterone levels. This was not an easy task given that men emit millions of sperm in each, while women only produce one egg per month. The pill has proven to be 100% effective in preliminary clinical trials and is completely reversible. The pill contains desogestrel, a synthetic hormone that is the main component in the female pill, as well as the male hormone testosterone. This combination blocks the production of sperm while maintaining male characteristics and sex drive. As with the female contraceptive pill, it must be taken daily. In terms of effectiveness, the male pill seems to be the best. In clinical trials, all of the participants’ sperm counts dropped to zero, which means that the male pill would be more effective than the condom and even the female pill