Endometriosis is when there is an abnormal growth of the endometrial cells, the cells that are similar to those which form inside the uterus, but in this case it grows outside of the uterus. Commonly they are found on other organs of the pelvis. This disease is most commonly found in women who are having infertility issues but does not completely prevent conception. Most of the time there are no symptoms found pertaining to this disease so there is not treatment as it is not necessary. There may be pelvic pain during menstruation or ovulation but these symptoms also ...view middle of the document...
These cells attach themselves to tissue outside of the uterus and are referred to as endometriosis implants. These implants are normally found on the lining of the pelvic cavity, the fallopian tubes, the ovaries, and outer surfaces of the uterus or intestines. They may also be found in the bladder, cervix, and vagina, although these areas are less common than the other locations in the pelvis. It is also possible for endometriosis implants to occur outside of the pelvis, in areas such as the liver, old surgery scars, or even in or around the brain or lungs.
“Because of the lack of evidence to substantiate the idea of a common genetic mutation in endometriosis, the familial tendency of endometriosis might alternatively be attributable to epigenetic reprogramming during embryonic or fetal development.” (Dean et al.)
Endometriosis seemingly impacts all aspects of the reproductive system in a negative manner; although it is subtle it is still significant. Not all patients respond to the therapies in the same way which makes production of new treatments inevitable. Research needs to be pursued, particularly in regards to targeting the molecular mechanisms. Animal models have been proven to be valuable in providing insight to principles of mechanisms underlying subfertility in endometriosis, when these studies in women are ethically restricted.