This website uses cookies to ensure you have the best experience. Learn more

Computational Analysis Of Single Nucleotide Polymorphism (Snps) Of Liver Cancer, Breast Cancer, And Lung Cancer

865 words - 4 pages

Synopsis of
Computational Analysis of Single Nucleotide Polymorphism (SNPs) of Liver cancer, Breast cancer, and Lung cancer

B.Sc Hons. Biotechnology

Institute of Industrial Biotechnology

Single nucleotide polymorphisms (SNPs), present in the protein encoding regions of the genome can have a profound influence on the structure and function of a protein. Simply these are the changes that could be silent or can be expressive, but mostly are silent. SNPs sometimes have very deleterious effects, such as change in only one nucleotide can cause missarrangement of whole of the sequence and thus codon is misread, ...view middle of the document...

This purpose will be done by searching the genes in which presence of the SNPs is reported. Then to collect total data for all the SNPs for all the specified genes will be done through using different databases such as dbSNP, Picsnp, or SNPedia. FASTA sequence of SNPs and other gene information will be retrieved on excel sheet. Such as “Gallbladder Cancer ” a type of Liver cancer fas been reported to have changes in following genes.


Gene Name SNPs in Humans Total SNPs
XRCC1 496 893
OGG1 238 362
ERCC2 318 699
MSH2 1457 3525
CASP8 557 1034
TLR2 233 1064
TLR4 226 611
PTGS2 167 342

Gene Position Change
Wild Varient
XRCC1 201 A C
201 C T
201 G T
201 C T
201 A C
201 A C
201 G T
201 C G
201 A C
201 A G
201 A G
201 C T
201 A G
201 A G
201 A T
201 A T
201 C G
Alongwith this FASTA sequence of flanking portion will also be displayed.
After this “Data Collection” step different softwares will be used for computational analysis of SNPs such as SIFT, SNP Detector, PolyPhen, UTRScan. After the complete analysis of SNPs different softwares for the codon level analysis of these changes will be used, so that complete information about the disease from top to bottom level will be available at one place. By this role of SNPs in the development of cancer will become possible.


Yokota.J and Kohno.T., 1999. How many tumour suppressor genes are involved in human lung cancer. Carcinogenesis. 8(20):1403-1410.
Teufel.A., Staib.F, Kanzler.S., Weinmann.A.,...

Other Papers Like Computational Analysis of Single Nucleotide Polymorphism (Snps) of Liver Cancer, Breast Cancer, and Lung Cancer

Breast Cancer Essay

926 words - 4 pages only a couple of sites that are typical of breast metastasis including bone, brain, liver, and lung. When the primary cancer site has developed in other areas of the body, it is unlikely that it will metastasize to the breast. The most common sites of metastatic disease in all types of cancer is brain, bone, liver, and lung. The American Cancer Society defines breast cancer as a “malignant tumor that starts in the cells of the breast. A malignant

Breast Cancer Essay

1297 words - 6 pages that has spread to the skin of the breast may also be inflammatory breast cancer. See the section on Inflammatory Breast Cancer for more information. For treatment, stage IIIC breast cancer is divided into operable and inoperable stage IIIC. Stage IV Enlarge Stage IV breast cancer. The cancer has spread to other parts of the body, most often the bones, lungs, liver, or brain. In stage IV, cancer has spread to other organs of the body, most often the bones, lungs, liver, or brain.

Breast Cancer

1503 words - 7 pages men to have breast cancer. Breast and Adjacent Lymph Nodes "Breast Cancer." Breast, n.d. Web. 13 Nov. 2013. A woman's breast is made up of many parts (as seen in the picture). There are the lobes. Inside a woman's breast are 15 to 20 sections, or lobes. Each lobe is made of many smaller sections called lobules. Lobules are milk-producing glands. Then there are the ducts, which are tiny tubes that carry the milk from

Breast Cancer - 799 words

799 words - 4 pages Signs and Symptoms Signs and Symptoms Breast Cancer Breast Cancer The most common symptom of breast cancer is a new lump or mass. A mass that is painless, hard, and has irregular edges is more likely to be cancerous, but breast cancers can be tender, soft, or rounded. They can even be painful. For this reason, it is important to have any new breast mass or lump, or breast change checked by a health care professional experienced in

Breast Cancer - 2214 words

2214 words - 9 pages has spread to tissues near the breast in the ribs and the muscles in the chest. The cancer has spread to lymph nodes inside the chest wall along the breast bone. Stage 4 The cancer has spread to other parts of the body such as the bones, lungs, liver, or brain. Diagnosis There are several tests used in the diagnosis of breast cancer. Mammography A mammography is an x-ray taken to examine the

Breast Cancer - 1523 words

1523 words - 7 pages BREAST CANCER Cancer is a disease caused by an uncontrolled division of abnormal cells in a part of the body. All around our world one may hear the word cancer, but have we ever taken the time to figure out exactly what cancer may be? There are many different types of cancers that one can be diagnosed with such as bone cancer, lung cancer, and breast cancer. I became curious about breast cancer a few years back and I

Breast Cancer - 619 words

619 words - 3 pages Breast Cancer Breast cancer is a growth of cancerous cells in the breast most common in woman, but it can occur in men. Breast cancer is caused when healthy tissue in the breast begins to grow abnormally, these cells grow and divide and create more abnormal cells forming a lump or tumor. Breast tumors can be classified as either; benign – this is a tumor that grows in one place and may not cause a problem, and is considered non- cancerous

Breast Cancer - 1682 words

1682 words - 7 pages Breast Cancer Breast cancer is a disease that is becoming more and more popular in this day of age. One in every eight women is diagnosed with breast cancer (Breast Cancer, 2010). Women and men who suffer from breast cancer not only are fighting cancer but are also fighting the psychological aspects of the disease. Breast Cancer is the second most diagnosed cancer among women in the United States right behind skin cancer. Women are now

Breast Cancer - 571 words

571 words - 3 pages . Those whom are at a risk for breast cancer are women age 20 to 39 with no family history of breast cancer, women between age 40 to 49 with no family history of breast cancer and women under age 50 with risk factors for breast cancer (such as family history) and women 50 to 70 and women over age 70. Each of these women ranging in different age groups is required to have a breast examination. Although cancer can often be treated, in most

Breast Cancer - 1458 words

1458 words - 6 pages increase a woman’s risk of breast cancer. Breast cancer can leave physical as well as emotional scars on those affected by this disease. It is likely that someone in your family or someone you know has had or will have breast cancer and has or will experience the devastating effects. My sister was diagnosed with stage III breast cancer, this paper is for her. Breast Cancer : Early Detection Saves Lives For years a woman’s examination

Breast Cancer - 2030 words

2030 words - 9 pages Breast Cancer COM/156 May 3, 2012 Breast Cancer Breast Cancer is the most common cancer that women may face in their lifetime. It can occur at any age, but is more likely to occur after the age of 40 and as we get older. Breast cancer is an unrestrained growth of breast cells, which take places as a result of modifications, or abnormal changes in the genes, that is responsible for stabilizing the growth of cells and keeping them healthy

Related Essays

Prevention Of Breast Cancer Essay

2751 words - 12 pages November 15, 2011, from Hunter, D., Spiegelman, D., Adami, H., Beeson, L., van den Brandt, P., Folsom, A., & Fraser, G. (1996, February 8). Cohort Studies of Fat Intake and the Risk of Breast Cancer — A Pooled Analysis. New England Journal of Medicine, 356-361. Retrieved November 15, 2011, from Jonsson, H., Nyström, L., Törnberg, S

Lung Cancer Essay

1420 words - 6 pages to polymorphism in chromosomes 5, 6 and 15 provokes 8% of all lung cancer cases. ( American cancer society, 2014) . Lung cancer also called pulmonary carcinoma or carcinoma of the lung. It is characterized by abnormal cell growth in the lung tissue that caused by DNA damage and epigenetic changes. It provokes disorders in cell functioning that include apoptosis or programmed cell death, cell growth or proliferation and DNA repair

Lung Cancer Essay

1897 words - 8 pages symptoms at least 12 days a month for at least six months, further examination is warranted as it could be an indication of a more serious condition, in particular ovarian Cancer. Ovarian cancer only accounts for 3 percent of cancers in women, yet it is the fifth most common cause of cancer death behind lung, breast, colorectal, and pancreatic cancers. Out of every 100,000 women, 12.5 of them will be diagnosed with ovarian cancer. It does not

Smoking And Lung Cancer Essay

1482 words - 6 pages , chemotherapy, oxygen therapy, and surgery (Beers). The purpose of this paper is to examine smoking and lung cancer by summarizing two articles on the topic, comparing and contrasting the main points presented by both authors and drawing conclusions as a result of analysis of these articles. According to Po-Huang Chyou and others in the article “A Prospective Study of the Attributable Risk of Cancer Due to Cigarette Smoking,” a study was done to