ENG122: English Composition II
Instructor: Peter Kunze
July 29, 2012
Childhood obesity is an issue that has become more evident of a problem as the years have changed. I am interested in the facts as to how a child becomes obese and if there are any ways to either prevent it or overturn it. I want to prove that obesity weighs more heavily on nature rather than nurture. There are specific genes that some people have and some people don’t have that attribute to becoming obese. I know the schools are doing a lot to keep kids more fit and active these days. First Lady Michelle Obama has played a huge role in helping ...view middle of the document...
Knowing the information about Ad-36 will prove to become very useful in the future. It has become quite troublesome for scientists to figure out exactly what to do with the information of this gene. This is not the only gene associated with obesity.
The mutated gene found in the brain cells, melanocortin-4 recepter, plays a role in regulating hunger. “Nearly 6 percent of morbidly obese children and adults have a genetic defect that keeps them feeling like their stomach is running on empty no matter how much they have eaten(Gentetics is a very strong component of obesity, 2006a”). The University of Flordia have determined that some of these mutations cause the receptor to miss signals that molecules try and tell the body when to eat and when you are full(Genetics is a very strong component of obesity, 2006b). Knowing this will hopefully help scientist to discover the glitch in the molecule and be able to make a drug to counter act against it.
It is becoming ever more evident that genes associated with the brain are to blame for obesity. “NRXN3 is the third obesity-associated gene to be identified. The fact that all three genes are highly active in encoding brain proteins is significant (new gene discovery links obesity to the brain, 2009a”). Since NRXN3 is active in the brain and also implicated in addiction, these traits may share some neurologic underpinnings. Although there is not enough data to suggest a direct connection between drug abuse and obesity, there can be an indirect infer link because both traits have the common gene (new gene discovery links obesity to the brain, 2009b).
Some other genes that have been associated to obesity are, Leptin, which regulates satiation and metabolism, Melanocortin, which is associated with feeding behavior and binge eating, Ghrelin, the stimulation of appetite, Neuromedin β, again feeding behavior and satiety, PROP, the preference of taste, PPAR, the fat metabolism, Mitochondrial uncoupling proteins, the expenditure of everygy, Melanocortin and MC4R, also the expenditure of energy(Addressing the obesity epidemic: A Genomics perspective, 2007a). The search for specific genes associated with obesity provides a foundation for understanding the effect of environmental and lifestyle factors on the development of obesity. Evidence suggests that genetic factors are involved in all aspects of weight regulation, including food intake and energy expenditure. Hunger or appetite, eating behavior, taste, satiety, spontaneous physical, metabolic rate, thermogenesis, and motivation to exercise all appear to have genetic correlates. Most single-gene disorders identified to date are associated with mutations in genes that regulate appetite (Addressing the obesity epidemic: A Genomics perspective, 2007b).
It is very important to discover these genes existent in a child and be more aware of what that child does to stay fit and healthy. Childhood obesity is a huge threat to health as a nation (Green, et al.,...