Alzheimer Essay

901 words - 4 pages

Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: An argument for multiple comparisons correction
Craig M. Bennett1, Abigail A. Baird2, Michael B. Miller1, and George L. Wolford3
1 3

Psychology Department, University of California Santa Barbara, Santa Barbara, CA; 2 Department of Psychology, Vassar College, Poughkeepsie, NY; Department of Psychological & Brain Sciences, Dartmouth College, Hanover, NH

INTRODUCTION
With the extreme dimensionality of functional neuroimaging data comes extreme risk for false positives. Across the 130,000 voxels in a typical fMRI volume the probability of a false positive is almost certain. Correction for multiple ...view middle of the document...

Analysis. Voxelwise statistics on the salmon data were calculated through an ordinary least-squares estimation of the general linear model (GLM). Predictors of the hemodynamic response were modeled by a boxcar function convolved with a canonical hemodynamic response. A temporal high pass filter of 128 seconds was include to account for low frequency drift. No autocorrelation correction was applied. Voxel Selection. Two methods were used for the correction of multiple comparisons in the fMRI results. The first method controlled the overall false discovery rate (FDR) and was based on a method defined by Benjamini and Hochberg (1995). The second method controlled the overall familywise error rate (FWER) through the use of Gaussian random field theory. This was done using algorithms originally devised by Friston et al. (1994).

A t-contrast was used to test for regions with significant BOLD signal change during the photo condition compared to rest. The parameters for this comparison were t(131) > 3.15, p(uncorrected) < 0.001, 3 voxel extent threshold. Several active voxels were discovered in a cluster located within the salmon’s brain cavity (Figure 1, see above). The size of this cluster was 81 mm3 with a cluster-level significance of p = 0.001. Due to the coarse resolution of the echo-planar image acquisition and the relatively small size of the salmon brain further discrimination between brain regions could not be completed. Out of a search volume of 8064 voxels a total of 16 voxels were significant. Identical t-contrasts controlling the false discovery rate (FDR) and familywise error rate (FWER) were completed. These contrasts indicated no active voxels, even at relaxed statistical thresholds (p = 0.25).

VOXELWISE VARIABILITY

DISCUSSION
Can we conclude from this data that the salmon is engaging in the perspective-taking task? Certainly not. What we can determine is that...

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